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Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator

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If ultrasound imaging is inconclusive but clinical suspicion remains, an MRI scan may be warranted to further assess

As shown in summary tables in section XXIII.A.10, we estimate a total information collection and reporting burden decrease of 6,924,988 hours at a savings of $178,884,367 annually associated with our proposals for the CY 2028 reporting period/CY 2030 payment determination and subsequent years compared to our currently approved information collection burden estimates under OMB control number 0938-1109 (expiration date January 31, 2026)

Some of the most common are nausea, vomiting, diarrhoea and for around 24% of users constipation