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Notably, methodological developments we have emphasized include transfer learning of pretrained models from large cohorts, multimodal models fusing imaging information with clinical and/or genomics, explainability techniques for the interpretation of models-e.g., saliency maps, Grad-CAM-and federated learning methods to address privacy and generalization issues across institutions

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However, considering GHKs high affinity for copper (see below) and essentiality of copper for cell growth, it is virtually impossible to have copper-free GHK in a living system

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There is a meaningful difference between mechanistic plausibility and clinical evidence in humans