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Creatine supplementation attenuates cognitive decline following sleep deprivation

Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)

Patients with pernicious anemia should be instructed that they will require monthly injections of Vitamin B12 for the remainder of their lives

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doi: 10.1007/7651_2021_366