Diabetic retinopathy Diabetic retinopathy is an eye condition caused by high sugar levels in the blood
McDonald 2012
While standard therapies, such as glucocorticoids, beta-2 adrenergic receptor (2AR) agonists, and biologics (e.g., anti-IgE, anti-IL-5, anti-IL5R, anti-IL4R) are effective in T2 high asthma, their efficacy is often diminished or non-existent in T2 low or metabolically driven asthma phenotypes
Unlike NDH-2 and Ndi1 contain Glu at this position (Glu198 of NDH-2, Glu273 of Ndi1), which interacts with adenine ribose moiety of NAD and thus determines Ndi1 or NDH-2 selectivity for NADH over NADPH 8,25 , cFSP1 contain His173 (His174 for hFSP1) at the corresponding position and would have a different selectivity comparing with Ndi1 and NDH-2
Glutathione levels decline with age and are depleted by oxidative stress