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347,348 Aging-related NAD + decline causes mitochondrial dysfunction Combining the evidence that mitochondrial dysfunction is a hallmark of aging and NAD + plays a crucial role in the maintenance of mitochondrial function

These results revealed previously unknown metabolic phenotypes, identified new developmental states of the metabolic correlation network, and underscored the role of mitochondrial functional changes, purine metabolism, and purinergic signaling in autism spectrum disorder

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