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Cagrilintide was specifically engineered with molecular modifications to resist rapid breakdown in the body and bind effectively to amylin 1 and 3 (AMY1R, AMY3R) receptors in the brain, allowing for a more stable, once-weekly dosing regimen compared to the multiple daily injections required for older amylin analogues like pramlintide
While Novo's Wegovy lists for $1,350 per month, in March the average net price for the drug was $616 according to an analysis by the Institute for Clinical and Economic Review
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