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These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) a marker of central obesity showed no consistent change, and the benefit appeared greater in women and with longer treatment durations

GPX4 has been identified as a critical factor for the development and function of MZB and B1 cells but does not have such effects on follicular B cells (108)

Explorations in silico for bioactive compounds revealed antioxidants and anti-inflammatory constituents to support the uroprotective outcome of AEECC (Anjum et al., 2023b)

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As to a connection with ER stress, many xenobiotics have been shown to influence the UPR signalling route, with either pro-survival or pro-death features - unsurprising given that resident CYP straddle ER membranes (84)