As humans, we need our tribe, you know? I kept thinking about how our species has long been more easily persuaded by a good story than hard evidence, that opting in has been more evolutionarily advantageous than opting out
(I wonder what the GLP-17-Pro will look like.) What I find particularly interesting are the differences in their effects and underlying biology
While Glu9 of GLP-1 formed strong and persistent hydrogen bond and van der Waals interactions with R190 2.60 , Y152 1.47 , and to a lesser extent, Y148 1.43 , the polar side chain of Gln3 in oxyntomodulin only formed weak and very transient hydrogen bonds with these residues, and van der Waals interactions only with Y148 1.43 (Movie S1, Supplementary Table 3)
Referenced Citations Ahrn, B., et al., Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials
Ozempic works best when combined with a healthy diet and lifestyle habits