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Although the role of elevation of decrease of the basal level of IEG mRNA is less clear, some studies have linked increased basal expression of Arc in the hippocampus of aged rats with spatial memory deficits (115)
(PubMed) Ferri N, Yokoyama K, Sadilek M, et al
The iron-sulfur complex assembly (ISC) complex consists of the cysteine desulfurase sub-complex NFS1-ISD11-ACP1, the scaffold protein ISCU2, the electron donor ferredoxin FDX2, and frataxin, a protein dysfunctional in Friedreichs ataxia 29
This action is believed to play a major role in its ability to help induce and maintain restful sleep
This intricate crosstalk highlights the interconnectedness of the gut-brain axis, where disruptions in microbial balance (dysbiosis) or microglial dysfunction can contribute to neurodegenerative and neuroinflammatory disorders Figure 1
