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We've observed institutional research protocols split daily doses above 100mg into twice-daily administration (morning and early evening) to maintain more stable plasma levels throughout the 24-hour cycle

Cochrane Database of Systematic Reviews , 5, CD012179

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The minimum level for B12 is around 180 ng/l however most healthy people have a level of around 500ng/l

Monitor and adjust early If symptoms return before the next dose, review dosing interval and cofactors instead of waiting