semaglutide natural form Compound Semaglutide

Incomplete and synergistic neutralization Incomplete (less than 100%) neutralization by mAbs at saturating concentrations is sometimes observed and may arise, for example, from glycan or conformational heterogeneity of Env spikes 103,104,105

Potential off-target effects: broad changes to methylation could, in theory, affect gene expression in ways not yet characterised

Genetic forms: Rare genetic mutations affecting folate metabolism (like DHFR or MTHFR mutations) can cause similar presentations and require different treatments

doi: 10.1111/jgh.14642 140 ChenYZhangPChenWChenG

Intracellular neutralisation of rotavirus by VP6-specific IgG