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Carbon 47 , 6872 (2009)

Fandio, J., Toba, L., Gonzlez-Matas, L

Vitamin D deficiency can impair regulatory T-cell function and promote the activation of proinflammatory T helper (Th)1 and Th17 cells, resulting in an enhanced autoimmune response

TML is then hydroxylated by 6-N-trimethyllysine dioxygenase (TMLD), which is located in the mitochondrial matrix, to form 3-hydroxy-6-N-trimethyllysine (HTML)