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, p38MAPK, ERK, and JNK)

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As a defined small molecule (not a peptide), it has different handling considerations than the rest of the Durham Peptides catalog, but the research utility is in the same conceptual category as NAD+-pathway research compounds

The treatment also decreased pro-inflammatory and pro-fibrotic gene expression with reduced macrophage infiltration (Li et al., 2025)

Research published in American Journal of Physiology (2019) demonstrated TB-500's ability to protect against ischemia-reperfusion injury in intestinal tissue