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Description

Chen Y, Saari JT, Kang YJ

Bioactive Materials, 32 , 502-513

While BPC-157 is noted to have a very short half-life (less than 30 min [51, 52]), the angiogenic, anti-inflammatory, and tissue regeneration processes it initiates appear to persist for weeks to months in animal studies, far exceeding the peptides pharmacokinetic presence [19, 53]

The authors hypothesised that xCT inhibition might be further potentiated by limiting glutamate or glutamine availability, and show that xCT is a compelling therapeutic target for triple-negative tumours