An ideal PD model would exhibit a high level of construct validity, indicating a similar disease pathogenesis (e.g., involving oxidative stress, inflammation, complex I inhibition, or proteasome inhibition), face validity, reflecting comparable symptoms (e.g., dyskinesia, rigidity), biochemistry (e.g., decreased striatal DA and altered downstream neurochemistry), and pathology (nigrostriatal tract degeneration and Lewy body formation) to the human condition, as well as predictive validity, signifying the capacity to accurately identify clinically effective treatments (Betarbet et al
Repetitive computer work, manual labor, cooking, gardening, and countless other activities can trigger the same degenerative process in these tendons
J Mol Med 2006
Both compounds independently cause nausea, vomiting, diarrhea, and constipation - especially during dose increases
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