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Guidelines from the American Diabetes Association and the European Association for the Study of Diabetes recommend GLP-1 medications as preferred agents for patients with atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease

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Similarly, GLP-1RAs exert the potential protection against inflammatory responses in T1DM through decreasing IFN- secretion and downregulating PD-1 expression in T cells by attenuating the Janus kinase (JAK)-STAT pathway [146, 147]