In addition to dopamine, norepinephrine, and epinephrine, the VMAT transporters, in particular VMAT2, are responsible for vesicular import of serotonin (5-HT), histamine, and several trace amines such as the tyramines [para-tyramine ( p -tyramine), meta-tyramine ( m -tyramine), 3-methoxytyramine, and N-methyltyramine], -phenylethylamine (-PEA), and thyronamine (3-iodothyronamine)
Semaglutide for managing overweight and obesity (TA875) Chapter 1: Recommendations
Patient counseling and education
Reports to the FDA describe cases requiring hospitalization for severe nausea, vomiting, dehydration, and pancreatitis following compounded tirzepatide dosing mistakes
Additionally, research is ongoing to determine whether these drugs can also be used to treat drug addictions, Alzheimers, and Parkinsons diseases (Beckwith, 2023)