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Empty stomach administration optimizes absorption similar to other peptides, with practical timing of 30 minutes before breakfast for morning administration or 2-3 hours after last meal for evening administration

10.1007/s00595-007-3706-2 [DOI] [PubMed] [Google Scholar] Nowak K

Criteria for its use are shown in Box 1

But combined with a GLP-1 receptor agonist it amplifies appetite suppression and adds distinct benefits through fat tissue and brain reward pathways that GLP-1 alone does not fully address