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In this study, metformin did not alter oxidative phosphorylation or glycolysis in normal non-cancer rectal tissue biopsies, importantly suggesting that the anti-metabolic effects of metformin may be tumour tissue-specific, which supports its potential utility as a radiosensitiser in rectal cancer

As clinicians, we've all encountered patients whose symptomsfatigue, mood swings, weight gain, low libidodon't align with their serum hormone levels

It activates the mTOR pathway, stimulating enzymes involved in nucleotide production

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