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14 Approximately 770 million adults live with obesity and 500 million with diabetes worldwide

Do not double up to make up for a missed dose

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There is no evidence of metabolic acceleration that would offset the natural decline in energy requirements accompanying weight reduction

Accordingly, such cells are sensitive to the glutaminase inhibitor CB-839, but are rescued from CB-839 toxicity by either lowering extracellular cystine or raising extracellular glutamate