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Impaired Absorption, Distribution, Metabolism, and Excretion of Nutrients and Other Substances Impaired digestion can lead to impaired ADME (absorption, distribution, metabolism, and excretion of nutrients), and acid reflux, as the digestive tract no longer becomes able to optimally carry out its functions
It was a peptide
Medical Contraindications These include a personal or family history of medullary thyroid carcinoma, a diagnosis of Multiple Endocrine Neoplasia syndrome type 2, or known hypersensitivity to semaglutide or other medication components
Future randomised controlled trials are needed to substantiate these associations, clarify the underlying mechanisms, and guide patient selection for optimal benefit