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Ligand-modified probes can increase the binding of probes to cancer cells and decrease distribution in normal tissue

You can read the abstract of this article at 104-OR: Novel GIP/GLP-1/Glucagon Receptor Agonist LY3437943: A First-in-Human Dose Study in Healthy Subjects | Diabetes | American Diabetes Association (diabetesjournals.org)

Kindel, T

Research teams that assume 'endogenous molecule = safe to combine' are ignoring receptor affinity data and downstream signaling cascades that create risk independent of molecular origin