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Even though many assume getting lighter naturally makes movement easier, activity levels declined rather than improved after patients started treatment, regardless of how much weight they lost

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The most frequently reported adverse events were gastrointestinal, primarily nausea, which was dose dependent

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To further explore the potential mechanism of GLP-1R, LY294002, a specific PI3K/Akt inhibitor was used to treat chondrocytes combined with liraglutide treatment