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People with this chronic, progressive neurological disorder have high levels of oxidative stress and premature cellular die off in a part of the brain called the substantia nigra

This is a class effect of GLP-1 receptor agonists

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al

Heart rate is also phenotype-coupled: near zero at 1 mg in the obese trial cohort, but +10 bpm or more at the same 1 mg in a leaner body from Phase 1b