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This is a normal physiological response to significant caloric and weight changes, not a sign that something is wrong

The effect of BC on metal bioavailability also varies with particle size, with smaller particles demonstrating a greater ability to adsorb heavy metals and reduce their bioavailability by 30% more than particles larger than 5 mm (Lebrun et al

With the improvement in the bioavailability of polyphenols, the potential and breadth of their clinical research are also increasing

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Adjustment: If response is inadequate, dose may be increased to 1.25 mg/kg (maximum)