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doi:10.1016/j.peptides.2023.171003 Jastreboff AM, Kaplan LM, Fras JP, et al

The most common clinical cause for concern about a pigmented lesion is a reported changing mole. In an otherwise previously uniform symmetric nevus, such changes typically include an increase in size, the formation of irregular borders with adjacent normal skin, and a peripheral change in color

Preclinical studies show improved mitochondrial biogenesis and reduced cellular senescence markers in metabolic tissues

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