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All but five of the genome-wide significant ancestry-specific GWAS variants were additionally found to be significant in the cross-ancestry meta-analysis
doi: 10.1016/j.eclinm.2025.103680 161 ErvinCNorcrossLMallyaUGFehnelSMittlemanRSWebsterMet al
Furthermore, ALA has a strong safety profile, rendering it a propitious option for the management of many medical conditions
2020;64(10):e00250-e320
This provides a rationale for the effect of mutagenesis of R190 2 .60 and K197 2 .67 , which were two of the few TMD residues that had a large impact on exendin-P5 affinity (Supplemental Figures 5 & 9)
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