tirzepatide/ niacinamide Tirzepatide + Niacinamide: Clinical Rationale & Safety – PlexusDx tirzepatide niacinamide dosage AFTER EMPOWER

The trial showed that tirzepatide was noninferior to dulaglutide in terms of threepoint MACE and superior across multiple secondary end points, including glycemic control, body weight, triglycerides, BP, renal function, and allcause mortality

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Efficacy comparison by clinical trial data The most relevant head-to-head data comes from the SURPASS-2 trial (tirzepatide vs semaglutide 1 mg for type 2 diabetes) and the SURMOUNT-5 trial (tirzepatide vs semaglutide 2.4 mg for obesity)

Given the observational and exploratory nature of this study, no formal adjustment for multiplicity was applied to the secondary or exploratory outcomes