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Unlike many drugs that act directly on muscle tissue, baclofen works by mimicking the neurotransmitter gamma-aminobutyric acid (GABA), but it primarily activates GABA-B receptors

This is actually advantageous for widespread eczema, where applying topical treatments to large body surface areas is impractical and compliance-limited

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In some embodiments, the formulations or compositions described herein have a osmolarity of about 100 mOsm/L to about 500 mOsm/L, about 200 mOsm/L to about 400 mOsm/L, about 250 mOsm/L to about 350 mOsm/L, or about 280 mOsm/L to about 320 mOsm/L

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