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Its cardiovascular safety in patients with cardiovascular disease or high cardiovascular risk was demonstrated in the aforementioned PIONEER-6 study.62 In the PIONEER 5 study, in patients with CKD stage 3, it was evaluated the efficacy and safety of a 14 mg dose, resulting superior to placebo in terms of reduction of HbA1c (-0.8% vs

doi: 10.3389/fphar.2022.791376 55 SunKGuoZHouLXuJDuTXuTet al

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Gonadotrophin deficiency due to mass effects of pituitary adenomas or gonadotrophin suppression due to cortisol or prolactin excess might induce insulin resistance in men and women that can be improved by hormone replacement therapy

( Pharmaceuticals , 2026) reviewed BPC-157 in Achilles tendon repair and muscle-to-bone healing, with proposed mechanisms involving EGR-1 gene upregulationa transcription factor important in tendon and ligament repair