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FeSOD and MnSOD are belonging to a homologous group and playing an important role in the living organism ( Streptococcus thermophilus AO54 and LMG 18311 contain a single MnSOD which are not sensitive to H 2 O 2 treatment in the presence of high Mn concentration ( Lactobacillus casei Shirota

The enzyme DT-diaphorase, another antioxidant marker, was elevated in young exercised rats, suggesting age-specific enzymatic adaptations to exercise (51)

While dietary interventions emphasizing protein, fiber, and whole foods can improve metabolic parameters and support weight management, the effects are generally more modesttypically 3-5% weight loss and HbA1c reductions of 0.5-1.0% when implemented without other interventions, as seen in programs like the Diabetes Prevention Program

Gene variants on genes such as MTHFR encoding methylenetetrahydrofolate reductase, MTR encoding methionine synthase, MTRR encoding methionine synthase reductase and CBS encoding cystathionine-B synthase in the methylation pathway can lead to a decreased ability to create sufficient methyl donor (SAMe) and may lead to disruptions in the SAMe:SAH ratio, thus altering methylation capacity and epigenetic regulation

Some worry about GLP-1 weight regain if treatment stops, which can add hidden costs later