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41,42 In addition, Wang et al 43 confirmed that ER stress decreases the eNOS phosphorylation and the generation of NO in rats aortic endothelial cells, which can be reversed by ER stress inhibitors

Together, these actions: Increase insulin release only when blood glucose is elevated Reduce excess glucose production by the liver Slow stomach emptying, limiting post-meal glucose spikes Act on appetite centres in the brain, increasing fullness and reducing hunger Because insulin release is glucose-dependent, Mounjaro on its own has a low risk of causing hypoglycaemia (low blood sugar), unless combined with insulin or sulfonylurea medications

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