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Glucagonomas are pancreatic cancers that secrete glucagon

In vacuoles of macrophages where phagocytosed bacteria are killed, itaconate inhibits the bacterial enzyme, isocitrate lyase (ICL), a bacterial enzyme required for the glyoxylate shunt that functions during host infection by bacteria

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Common variants include: GSTM1 null : 40-50% of population-reduced capacity to neutralize environmental toxins GSTP1 variants : Impaired detoxification of carcinogens 6