Type II collagen (COL II) is one of the major components of the cartilage extracellular matrix (ECM), and the distribution of COL II could reflect neocartilage formation directly in the defect area
e-GST levels in cows raised in highly polluted areas Preliminary data obtained analyzing blood samples from 10 cows reared in farms located in a well-known polluted area (River Sacco valley, located in the Frosinone district, Lazio, Italy) showed that e-GST is overexpressed, displaying an average value of 183 U/g Hb , much higher than that found in the samples obtained from controlled farms located in unpolluted areas (10.70.4 U/g Hb ) (Figure 1a)
The treatment was well tolerated with no adverse events and no changes in vital signs, electrocardiograms, or laboratory markers assessing cardiac, liver, kidney, thyroid, or metabolic function
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EMT is observed in the process of renal interstitial, pulmonary and liver fibrosis [56,57,58,59], as well as in specific ocular tissue [32]
