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Studies have shown that simultaneous blockade of both activin A and MSTN, both ligands of ActRIIA/B, produces greater increases in muscle mass than inhibiting either alone.[82] This finding is supported by clinical trials, where combined treatment with trevogrumab (anti-MSTN) and garetosmab (anti-activin A) increased total body muscle volume and reduced fat mass compared with placebo or either antibody alone.[83] Overall, activin A inhibitors are as promising as MSTN inhibitors, and their combination may yield superior outcomes

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