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A placebo-controlled study of 72 patients with type 2 diabetes found that oral administration of lipoic acid at doses of 600 mg/day, 1,200 mg/day or 1,800 mg/day improved insulin sensitivity by 25% after four weeks of treatment (58)

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"Interaction of dihydrofolate reductase with methotrexate: Ensemble and single-molecule kinetics"