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The development of incretin-based therapy for T2DM began in the 1990s, with the widespread use of daily short-acting injectable GLP-1 receptor agonists and oral dipeptidyl peptidase-4 inhibitors occurring in the 2000s

[DOI] [PMC free article] [PubMed] 62.Mehta, P

(BPC 157 angiogenesis / NO-system review)

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The interpretation of these transcriptomic findings has been a continuing area of discussion, with some researchers viewing the broad effects as evidence of a regulatory function and others viewing them with caution given the difficulty of distinguishing direct effects from secondary consequences in such broad gene-expression landscapes