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It is important to note that the medical use of methandienone has been largely discontinued and withdrawn in most countries due to these strong side effects, and it is primarily used non-medically for performance enhancement, often illegally

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Elevated levels of F2 isoprostanes (prostaglandin-like substances derived from lipid peroxidation) in serum and urine from SLE patients have been reported [43]

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However, exercise has been proven to enhance cardiac function by upregulating the activity of myocardial oxidative stress-related enzymes, thereby increasing the expression of two key ferroptosis biomarkers, GPX4 and PTGS2, and inhibiting myocardial ferroptosis (81, 82)