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The relationship between these two compounds is a partnership, not a competition

For example, detachment of the radioulnar ligaments usually requires open repair

It can inhibit a key step of the folate cycle (at the level of 5-methyltetrahydrofolate), leading to the accumulation of AICAR a natural analog of AMP that potently activates AMPK

A Phase I trial confirmed that just 5 low-dose subcutaneous injections produced measurable pigmentation changes in the face, upper body, and buttock (Dorr et al., 1996)