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Conclusions The publication of the 2024 NICE guidelines on B 12 deficiency represents progress but falls short by proposing to rename pernicious anaemia with autoimmune gastritis. This change does not adequately address the distinct nature of PA as an advanced stage of AIG, characterised by IF deficiency requiring lifelong B 12 treatment

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This regulation requires PPTC7, a conserved mitochondrial matrix PP2C phosphatase, which acts as a scaffold for assembling the substrate-PPTC7-SCF FBXL4 holocomplex that then facilitates degradation of BNIP3 and NIX [45, 46]

Meet the experts: Jamie Alan, PharmD, PhD, is an associate professor of pharmacology and toxicology at Michigan State University