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Key Takeaways Cagrilintide is a long-acting amylin analogue being studied for appetite regulation, satiety, body-weight reduction, and metabolic disease research

Peptide Structure Mechanisms of Action AMPK Activation: MOTS-c binds Folate cycle intermediates AMPK-Thr172 phosphorylation -oxidation & GLUT4 translocation

Proton pump inhibitors (ppis): these medications used to treat gastroesophageal reflux disease (gerd) can decrease the absorption of vitamin b12, increasing the risk of deficiency