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The studies reported improvements in spasticity and athetosis [126, 127, 132, 143, 147], as well as gait [129] and respiration [137]

In the STEP trials, participants taking semaglutide 2.4 mg weekly lost an average of 15% of their body weight over 68 weeks, compared to 2.4% in the placebo group

About 62% in the four study arms had diabetes, and body mass index averaged 35.8 kg/m2

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Importantly, intrinsic factors indicated by tirzepatides properties suggest that patients with hepatic and renal impairment may not require dosage adjustments, adding to the drugs potential versatility and applicability across a range of patient populations