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In contrast to the AR, the structural basis of antagonism has been elucidated for other nuclear receptors, eg , from the structures of 4-hydroxyltamoxifen (4-OHT) bound to the ER 91 , RU-486 bound to the GR 91,92 and the antagonist GW6471 bound to PPAR- 93

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To better observe the influence of UA on cardiomyocytes and LVR, we used a UA concentration of 15 mg/dL in in vitro experiments and a plasma UA concentration of 1020 mg/dL in i n vivo experiments