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These observations were further confirmed by Hoechst 33342 staining, which revealed extensive detachment of cells from the cell culture substratum and increases in apoptotic bodies of HepG2 cells incubated with H 2 O 2 and TNF for 16 h (Fig

Biomacromolecules 16(5):14891496

Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus

Obesity ranks as one of the most serious public health challenges today

In addition, elecoglipron showed clinically meaningful improvements in several exploratory analyses of cardiometabolic risk factors including lower blood pressure and C-reactive protein levels, a marker of systemic inflammation