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Hypoxia has recently been shown to downregulate thiamine transporters in a colonic cell line, impairing the thiamine uptake that results in a localized intracellular deficiency (190)

[4] The proposed mechanism of action, based only on preclinical animal studies, involves potential modulation of growth factor pathways, particularly vascular endothelial growth factor (VEGF), which may promote angiogenesisthe formation of new blood vessels

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Vitamin B12 B12 deserves its own mention because its deficiency is widespread and its consequences significant including fatigue, brain fog, and peripheral nerve symptoms

A recent study has further elucidated the correlation between neutrophil ferroptosis and SLE pathogenesis, identifying ferroptosis as the predominant mode of neutrophil death (83)