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Why Erectile Dysfunction Requires a Whole-Person Lens ED is rarely just one thing. As I explain to patients, the penis is a vascular organ governed by neurohormonal and psychogenic regulation, housed within a biomechanical framework (pelvis, lumbar spine, hips) and influenced by systemic inflammation and cardiometabolic health

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The complexity of neurosteroid-mediated effects, for instance gating of GABA A R (135139) and subunit-specific modulation of glycine and NMDARs (140), suggest the likelihood of multiple binding sites that contribute to potentiating and inhibitory effects ( A Rs also appears to involve modulation of subunit-containing receptors which play a role in tonic inhibition (141145)