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GLP-1 therapy may help improve insulin sensitivity, reduce cravings, support fat loss, and improve energy levels

According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver

NPJ Breast Cancer 6 , 12 (2020)

A useful comparison point is the acylation chemistry described for semaglutide by Lau and colleagues in the Journal of Medicinal Chemistry in 2015 [2], which introduced a C18 diacid linked through a spacer to achieve albumin binding on a GLP-1 scaffold

Other options, like the birth control implant, patch, or ring didnt have enough studies to determine if they are affected by these types of medications