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Clinical Pharmacology of GLP-1 RAs The approval of the first GLP-1 RA, exenatide, by the FDA in 2005 marked a significant advancement in treating diabetes and obesity

Specifically, Trx2 deficiency in adipocytes triggers NF-B-dependent p62 accumulation, which targets damaged mitochondria for excessive autophagy via polyubiquitination (143)

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Proponents claim these compounds enhance fat breakdown and liver function

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