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DIY dose splitting/dilution: Some patients may use insulin syringes or count clicks on the pen to draw out smaller amounts than the lowest marketed dose, or dilute the drug to create microdoses

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Among patients with type 2 diabetes, GLP-1 use was associated with a 32% lower risk of fracture for those with osteopenia and for those with osteoporosis, as seen in Figure 1

Therefore, the lower amount of IC50 represents higher toxicity of a compound leading to death or inhibition of cell growth

In contrast, a retrospective cohort study of 1,626 individuals of Chinese descent revealed a significantly lower incidence of DR in the GLP-1RA group compared to those treated with insulin or oral hypoglycemic agents