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At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

A systematic review and meta-analysis including 35 RCTs demonstrated that BCAA supplementation improved muscle strength (standardized mean difference [SMD]: 0.35) and muscle mass (SMD: 0.25) in older adults, though improvements in physical function did not reach statistical significance (53)

The Three Critical Limitations of Antihistamines 1

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